SMTP-1 and -2, novel analogs of staplabin produced by Stachybotrys microspora IFO30018.

Plasminogen is a circulating zymogen of plasmin, a primary fibrinolytic enzyme1}.Plasminogen binding to fibrin and vascular and blood cells increases the local concentration of the zymogenand accelerates the activation of plasminogen by plasminogen activators2). We have previously isolated a novel fungal triprenyl phenol, designed staplabin, which enhances plasminogen binding to fibrin and cultured cells3). In the present paper, we report the isolation of two novel analogs of staplabin from cultures of Stachybotrys microspora IFO30018. The analogs, designated SMTP-1 and -2, were iso-